pMEV2HA-IRAK4-KA

Human IRAK4 Xpress Clones encode a 52 kDa serine/threonine kinase involved in IL-1R/TLR signaling, essential for the activation of NF-κB and MAPKs. IRAK4 features a death domain (DD) and a kinase domain (KD) but lacks the extended C-terminal region seen in other IRAKs. Expression is highest in kidney and liver, with low levels in other tissues. A mutation in the ATP-binding site (KK213AA) renders IRAK4 kinase-inactive, significantly reducing IL-1-induced NF-κB activation, in contrast to kinase-deficient IRAK1. This underscores the critical role of IRAK4’s kinase activity in immune signal transduction, making these clones valuable tools for studying innate immunity and inflammation pathways. - 20 ug