NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis)(CPTC-NME1-2) , CF594 conjugate , 0.1mg / mL

The nm23 gene , a potential suppressor of metastasis , was originally identified by differential hybridization between two murine melanoma sub-lines , one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis , nm23 appears highly related to nucleotide diphosphate kinases (NDP-K). In humans , NDP kinase A and B are identical to two isotypes of human nm23 homologs , namely nm23-H1 and H2 , respectively. nm23-H2 is identical in sequence to PuF , a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human C-Myc promotor. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.