NuMA(A73-B/D12) , 1mg / mL

Recognizes a phosphorylated protein of 228 kDa , identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis , it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase , the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200 kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor , alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.This antibody is available purified with BSA/azide at 200 ug/ mL , or BSA/azide-free at 1 mg / mL.