Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) (KRT6/1702) , CF640R conjugate , 0.1mg / mL

This MAb recognizes a protein of 56 kDa , identified as cytokeratin 6 (CK6). In humans , multiple isoforms of Cytokeratin 6 (6A-6F) , encoded by several highly homologous genes , have distinct tissue expression patterns , and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13 , and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes , which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles , suprabasal cells of a variety of internal stratified epithelia , in epidermis , in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes , which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.