Cytokeratin 13 (Non-Keratinized Squamous Epithelial Marker)(KRT13/2213) , CF640R conjugate , 0.1mg / mL

Cytokeratin 13 (KRT13) is the major acidic keratin , which together with KRT4 , its basic partner , is expressed in the suprabasal layers of non-cornified stratified epithelia including tongue mucosa , esophagus , anal canal epithelium , tracheal epithelium , uterine cervix , and urothelium. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN) , a rare autosomal dominant disorder , which predominantly affects non-cornified stratified squamous epithelia and is characterized by the presence of soft , white and spongy plaques in the oral mucosa. KRT13 has been used as a marker for non-keratinized squamous epithelium. It is also expressed in various squamous metaplasia , but it is down regulated in squamous dysplasia and squamous carcinoma. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.