Cytokeratin 19(A53-B/A2.26) , CF555 conjugate , 0.1mg / mL

This MAb reacts with the rod domain of human cytokeratin-19 (CK19) , a polypeptide of 40 kDa. Its epitope maps between amino acid 312-335. CK19 is expressed in sweat gland , mammary gland ductal and secretory cells , bile ducts , gastrointestinal tract , bladder urothelium , oral epithelia , esophagus , and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon , stomach , pancreas , biliary tract , liver , and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type , although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes , peripheral blood , bone marrow and breast cancer.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.