Pmel17 / gp100 / SILV(PMEL/783) , CF568 conjugate , 0.1mg / mL
Cytotoxic T lymphocytes (CTLs) recognize melanoma-associated antigens , which belong to three main groups. These groups include tumor-associated testis-specific antigens , melanocyte differentiation antigens and mutated or aberrantly expressed antigens , which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. PMEL 17 , also designated gp100 , ME20-M , or ME20-S , is classified as a melanocyte differentiation antigen. It is expressed at low levels in normal cell lines and tissues , but is upregulated in melanocytes. It is a highly glycosylated , secreted protein that is the product of proteolytic cleavage.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.