PAX8 (Renal Cell Marker)(PAX8/2774R) , CF568 conjugate , 0.1mg / mL

Recognizes a protein of 62 kDa , identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis , thyroid follicular carcinomas , and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas) , non-ciliated mucosal cells of the fallopian tubes , and simple ovarian inclusion cysts , but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous , endometrioid , and clear cell carcinomas , but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma , nephroblastoma , and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.