Cyclin A1(XLA1-3) , CF568 conjugate , 0.1mg / mL

The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase , the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle , appears to be involved in control of S phase and has been shown to associate with cyclin-dependent kinase-2 (Cdk2). In addition , cyclin A has been implicated in cell transformation and is found in complexes with E1A , transcription factors DRTF1 and E2F , and retinoblastoma protein p110. A second form of cyclin A , named cyclin A1 because of its high sequence homology to Xenopus cyclin A1 , is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2 , p39 and Cdc2 p34. The antibody detects Xenopus cyclin A in blots. Cyclin A1 is the embryonic cyclin which is present in Xenopus eggs. This MAb only detects Xenopus Cyclin A1. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.