Ep-CAM / CD326(EGP40/826 + EGP40/837 + EGP40/1110 + EGP40/1120) , CF594 conjugate , 0.1mg / mL

This is a cocktail of four highly specific monoclonal antibodies (EGP40/826 , EGP40/837 , EGP40/1110 , EGP40/1120) that recognize extracellular as well as intracellular domains of the epithelial cellular adhesion molecule (Ep-CAM). Epithelial specific antigen (ESA) , or Ep-CAM , is a 40-43 kDa transmembrane epithelial glycoprotein expressed on the basolateral cell surface in most simple epithelia and a vast majority of carcinomas. This epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been suggested as a discriminator between basal cell and baso-squamous carcinomas , and squamous cell carcinoma of the skin._x000D_ _x000D_ Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_