Cytokeratin 10 (Suprabasal Epithelial Marker) (KRT10/844 + KRT10/1275) , CF594 conjugate , 0.1mg / mL

This MAb recognizes a protein of 56.5 kDa , identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis , expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer , appears in the first suprabasal layers and increases in concentration towards the granular layer. However , CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm , clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm , clinical stages II and III) , CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes , being preferentially detected in more-differentiated parts.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.