Desmin (Muscle Cell Marker) (DES/2960R) , CF594 conjugate , 0.1mg / mL

Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alphalpha-helicalcoiled-coil molecules arranged on an imperfect helical lattice , and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin , a related class III IF , are both expressed during skeletal muscle development. Desmin , a 469 amino acid protein found near the Z line in sarcomeres , is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth , skeletal , and cardiac muscles. The antibody reacts with leiomyomas , leiomyosarcoma , rhabdomyomas , rhabdomyosarcoma , and perivascular cells of glomus tumors of the skin.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.