Cytokeratin 6A (KRT6A) (Basal Cell Marker) (KRT6A/2368) , Biotin conjugate , 0.1mg / mL

This MAb recognizes a protein of 56 kDa , identified as cytokeratin 6A (KRT6A). In humans , multiple isoforms of Cytokeratin 6 (6A-6F) , encoded by several highly homologous genes , have distinct tissue expression patterns. Cytokeratin 6A is the dominant form in epithelial tissue. Cytokeratin 6 and 16 are expressed in keratinocytes , which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles , suprabasal cells of a variety of internal stratified epithelia , in epidermis , in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes , which express KRT6 and KRT16. KRT6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.