Clathrin , Light Chain (CLC/1421) , 0.2mg / mL

This antibody recognizes proteins of 31-44 kDa , which are identified as Clathrin Light Chains (both A & B). Clathrin is composed of three heavy chains and three light chains , which associate non-covalently to form a triskelion structure. Clathrin light chain regulates the self-assembly of triskelions onto intracellular membranes. Clathrin light chain subunits (LCA and LCB) contribute to regulation of coated vesicle formation to sort proteins during receptor-mediated endocytosis and organelle biogenesis. LCA and LCB are encoded by two discrete genes. They share only 60% homology , and have certain features in common. Both LCA and LCB undergo alternative mRNA splicing , which results in the generation of tissue-specific isoforms.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.