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Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/2593) , 0.2mg / mL

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Recognizes a protein of 36 kDa , identified as cyclin D1. Cyclin D1 , one of the key cell cycle regulators , is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally , hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

225,00 € 225.0 EUR 225,00 €

225,00 €

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Conditions générales
Garantie satisfait ou remboursé de 30 jours
Expédition : 2-3 jours ouvrables