LCN2 Monoclonal Antibody

Volume : 50 µg
Clone Number : 3B1C10
Aliases : NGAL,25 kDa alpha-2-microglob µLin-related subunit of MMP-9,Lipocalin-2
Product Type : Monoclonal Antibody
Immunogen Species : Human
UniProt ID : P80188
Immunogen : Recombinant Human Neutrophil gelatinase-associated lipocalin protein
Raised in : Mouse
Species Reactivity : Human,Mouse
Tested Applications : ELISA,WB;Recommended dilution : WB : 1 : 500-1 : 5000
Background : Iron-trafficking protein involved in m µLtiple processes such as apoptosis, innate immunity and renal development. Binds iron thro µgh association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracell µLar iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracell µLar siderophore, iron chelation and iron transfer to the extracell µLar medium, thereby reducing intracell µLar iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation : iron-loaded form increases intracell µLar iron concentration without promoting apoptosis, while iron-free form decreases intracell µLar iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, res µLting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Clonality : Monoclonal
Isotype : IgG2b
Purification Method : >95%,Protein G purified
Conj µgate : Non-conj µgated
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LCN2
Research Areas : Cancer?Cardiovasc µLar;Immunology?Metabolism;Signal transduction