ALOX12B Antibody HRP conjugated

Volume : 50 µL
Clone Number :
Aliases : ALOX12B antibody; Arachidonate 12-lipoxygenase antibody; 12R-type antibody; 12R-LOX antibody; 12R-lipoxygenase antibody; EC 1.13.11.- antibody; Epidermis-type lipoxygenase 12 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O75342
Immunogen : Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conj µgation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the reg µLation of the expression of airway mucins.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ALOX12B
Research Areas : Cardiovasc µLar; Cell biology; Metabolism; Signal transduction