ASPN Antibody

Volume : 50 µg
Clone Number :
Aliases : ASPN antibody; ASPN protein antibody; ASPN_HUMAN antibody; Asporin (LRR class 1) antibody; Asporin antibody; Asporin proteoglycan antibody; FLJ20129 antibody; LRR class 1 antibody; Periodontal ligament associated protein 1 antibody; Periodontal ligament-associated protein 1 antibody; PLAP 1 antibody; PLAP-1 antibody; PLAP1 antibody; SLRR 1C antibody; SLRR1C antibody; Small leucine rich protein 1C antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9BXN1
Immunogen : Recombinant Human Asporin protein (33-380AA)
Raised in : Rabbit
Species Reactivity : Human, Mouse
Tested Applications : ELISA, WB, IHC; Recommended dilution : WB : 1 : 1000-1 : 5000, IHC : 1 : 20-1 : 200
Background : Negatively reg µLates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, res µLting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical reg µLator of TGF-beta in artic µLar cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively reg µLates chondrogenesis in the artic µLar cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Non-conj µgated
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ASPN
Research Areas : Signal transduction