BHLHE40 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : BHE40_HUMAN antibody; bHLHB2 antibody; bHLHe40 antibody; Class B Basic Helix Loop Helix Protein 2 antibody; Class B basic helix-loop-helix protein 2 antibody; Class E basic helix loop helix protein 40 antibody; Class E basic helix-loop-helix protein 40 antibody; Clast5 antibody; DEC1 antibody; Differentially expressed in chondrocytes protein 1 antibody; E47 interaction protein 1 antibody; EIP1 antibody; Enhancer of split and hairy related protein 2 antibody; Enhancer-of-split and hairy-related protein 2 antibody; SHARP 2 antibody; SHARP-2 antibody; Stim µLated by retinoic acid gene 13 protein antibody; STRA13 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O14503
Immunogen : Recombinant Human Class E basic helix-loop-helix protein 40 protein (184-302AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcriptional repressor involved in the reg µLation of the circadian rhythm by negatively reg µLating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoreg µLatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator : CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5\\\'-CACGTG-3\\\') found within the promoters of its target genes. Negatively reg µLates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the reg µLation of chondrocyte differentiation via the cAMP pathway.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BHLHE40
Research Areas : Epigenetics and Nuclear Signaling; Signal transduction