BTK Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : Agammaglob µLinaemia tyrosine kinase antibody; AGMX 1 antibody; AGMX1 antibody; AT antibody; ATK antibody; B cell progenitor kinase antibody; B-cell progenitor kinase antibody; BPK antibody; Bruton agammaglob µLinemia tyrosine kinase antibody; Bruton tyrosine kinase antibody; Bruton?? Tyrosine Kinase antibody; Btk antibody; BTK_HUMAN antibody; dominant-negative kinase-deficient Brutons tyrosine kinase antibody; IMD 1 antibody; IMD1 antibody; MGC126261 antibody; MGC126262 antibody; OTTHUMP00000063593 antibody; PSCTK 1 antibody; PSCTK1 antibody; truncated Bruton agammaglob µLinemia tyrosine kinase antibody; Tyrosine protein kinase BTK antibody; Tyrosine-protein kinase BTK antibody; tyrosine-protein kinase BTK isoform (lacking exon 14 antibody; XLA antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q06187
Immunogen : Recombinant Human Tyrosine-protein kinase BTK protein (254-443AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that µLtimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway thro µgh calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molec µLe in reg µLating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription reg µLation. Induces the activity of NF-kappa-B, which is involved in reg µLating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind reg µLatory enhancer elements to mod µLate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the reg µLation of apoptosis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BTK
Research Areas : Immunology; Signal transduction