Ctcfl Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Ctcfl antibody; Boris antibody; Transcriptional repressor CTCFL antibody; Brother of the reg µLator of imprinted sites antibody; CCCTC-binding factor antibody; CTCF paralog antibody; CTCF-like protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Mus musc µLus (Mouse)
UniProt ID : A2APF3
Immunogen : Recombinant Mouse Transcriptional repressor CTCFL protein (1-636AA)
Raised in : Rabbit
Species Reactivity : Mouse
Tested Applications : ELISA
Background : Testis-specific DNA binding protein responsible for ins µLator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 \\\'Arg-3\\\' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : Ctcfl
Research Areas : Epigenetics and Nuclear Signaling; Cancer