DNA2 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : DNA replication ATP-dependent helicase-like homolog antibody; DNA replication helicase 2 homolog antibody; DNA replication helicase 2, yeast, homolog of antibody; DNA replication helicase 2-like antibody; DNA replication helicase/nuclease 2 antibody; DNA2 antibody; DNA2-like helicase antibody; DNA2L antibody; DNA2L_HUMAN antibody; HDNA2 antibody; KIAA0083 antibody; PEOA6 antibody; SCKL8 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P51530
Immunogen : Recombinant Human DNA replication ATP-dependent helicase/nuclease DNA2 protein (1-300AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1 : flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5\'-end resection of DNA during double-strand break (DSB) repair : recruited by BLM and mediates the cleavage of 5\'-ssDNA, while the 3\'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5\'-3\' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5\'-3\' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DNA2
Research Areas : Epigenetics and Nuclear Signaling