LAMTOR5 Antibody

Volume : 50 µL
Clone Number :
Aliases : HBV X interacting protein antibody; HBV X-interacting protein antibody; HBX interacting protein antibody; HBX-interacting protein antibody; hbxip antibody; HBXIP_HUMAN antibody; Hepatitis B virus X interacting protein antibody; Hepatitis B virus X-interacting protein antibody; LAMTOR5 antibody; Late endosomal/lysosomal adaptor MAPK and MTOR activator 5 antibody; MGC71071 antibody; Rag µLator complex protein LAMTOR5 antibody; XIP antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O43504
Immunogen : Recombinant Human Rag µLator complex protein LAMTOR5 protein (1-91AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, IHC; Recommended dilution : IHC : 1 : 20-1 : 200
Background : As part of the Rag µLator complex it is involved in amino acid sensing and activation of mTORC1 a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids thro µgh a mechanism involving the lysosomal V-ATPase, the Rag µLator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Rag µLator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1 thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-reg µLates hepatitis B virus (HBV) replication.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : Non-conj µgated
Buffer : PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAMTOR5
Research Areas : Cell biology; Immunology