MAF Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : AS42 oncogene homolog antibody; Avian musc µLoaponeurotic fibrosarcoma (MAF) protooncogene antibody; Avian musc µLoaponeurotic fibrosarcoma (v maf) antibody; c maf proto oncogene antibody; cMaf antibody; maf antibody; MAF_HUMAN antibody; MAF2 antibody; MGC71685 antibody; Proto oncogene c Maf antibody; Proto-oncogene c-maf antibody; Transcription factor Maf antibody; v maf musc µLoaponeurotic fibrosarcoma oncogene homolog (avian) antibody; v maf musc µLoaponeurotic fibrosarcoma oncogene homolog antibody; V-maf musc µLoaponeurotic fibrosarcoma oncogene homolog antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O75444
Immunogen : Recombinant Human Transcription factor Maf protein (55-180AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-reg µLation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter thro µgh the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5\'-[GT]G[GC]N[GT]NCTCAGNN-3\' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAF
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology; Immunology