MAPK12 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracell µLar signal-reg µLated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody; Mitogen-activated protein kinase 12 antibody; Mitogen-activated protein kinase p38 gamma antibody; MK12_HUMAN antibody; P38 GAMMA antibody; P38GAMMA antibody; PRKM12 antibody; SAPK 3 antibody; SAPK-3 antibody; SAPK3 antibody; Stress Activated Protein Kinase 3 antibody; Stress-activated protein kinase 3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P53778
Immunogen : Recombinant Human Mitogen-activated protein kinase 12 protein (314-367AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cell µLar responses evoked by extracell µLar stim µLi such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated thro µgh phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-reg µLation of cyclin D1 in response to hypoxia in adrenal cells s µggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1 thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and co µLd affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Reg µLates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the reg µLation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively reg µLates SLC2A4 expression and contraction-mediated glucose uptake in ad µLt skeletal muscle. C-Jun (JUN) phosphorylation is stim µLated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 reg µLation. MAPK12 is required for the normal kinetochore localization of PLK1 prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively reg µLating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK12
Research Areas : Cell biology; Signal transduction