MAPK13 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : MAP kinase 13 antibody; MAP kinase p38 delta antibody; MAPK 13 antibody; MAPK-13 antibody; Mapk13 antibody; MGC99536 antibody; Mitogen activated protein kinase 13 antibody; Mitogen-activated protein kinase 13 antibody; Mitogen-activated protein kinase p38 delta antibody; MK13_HUMAN antibody; OTTHUMP00000016282 antibody; OTTHUMP00000016283 antibody; p38 delta antibody; P38delta antibody; PRKM13 antibody; SAPK 4 antibody; SAPK4 antibody; Stress activated protein kinase 4 antibody; Stress-activated protein kinase 4 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O15264
Immunogen : Recombinant Human Mitogen-activated protein kinase 13 protein (1-365AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cell µLar responses evoked by extracell µLar stim µLi such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated thro µgh phosphorylation and further phosphorylate additional targets. Plays a role in the reg µLation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling thro µgh phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-reg µLation of the gene expression of CXCL14. Plays an important role in the reg µLation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-reg µLates PRKD1 during reg µLation of ins µLin secretion in pancreatic beta cells.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPK13
Research Areas : Cell biology; Signal transduction