ATF4 (Ab 219) Antibody

Volume : 100 µL
Clone Number :
Aliases : Activating transcription factor 4 antibody; ATF 4 antibody; ATF4 antibody; ATF4 protein antibody; ATF4_HUMAN antibody; cAMP-dependent transcription factor ATF-4 antibody; cAMP-responsive element-binding protein 2 antibody; CREB 2 antibody; CREB-2 antibody; CREB2 antibody; Cyclic AMP dependent transcription factor ATF 4 antibody; Cyclic AMP response element binding protein 2 antibody; Cyclic AMP-dependent transcription factor ATF-4 antibody; Cyclic AMP-responsive element-binding protein 2 antibody; DNA binding protein TAXREB67 antibody; DNA-binding protein TAXREB67 antibody; Tax Responsive Enhancer Element B67 antibody; Tax-responsive enhancer element-binding protein 67 antibody; TaxREB67 antibody; TXREB antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P18848
Immunogen : SyntheVolumed peptide derived from C-terminal of Human ATF4.
Raised in : Rabbit
Species Reactivity : Human, Mouse
Tested Applications : ELISA, WB; WB : 1 : 500-1 : 3000
Background : Transcriptional activator. Binds the cAMP response element (CRE) (consensus : 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cell µLar promoters. Cooperates with FOXO1 in osteoblasts to reg µLate glucose homeostasis thro µgh suppression of beta-cell production and decrease in ins µLin production By similarity. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Reg µLates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by reg µLating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4.

Tsujimoto A., J. Virol. 65 : 1420-1426(1991).
Karpinski B.A., Proc. Natl. Acad. Sci. U.S.A. 89 : 4820-4824(1992).
Dunham I., Nature 402 : 489-495(1999).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conj µgate : Non-conj µgated
Buffer : Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ATF4
Research Areas : Epigenetics and Nuclear Signaling