ATM (Ab 1981) Antibody

Volume : 100 µL
Clone Number :
Aliases : A-T mutated antibody; A-T mutated homolog antibody; AT mutated antibody; AT1 antibody; ATA antibody; Ataxia telangiectasia mutated antibody; Ataxia telangiectasia mutated gene antibody; Ataxia telangiectasia mutated homolog (human) antibody; Ataxia telangiectasia mutated homolog antibody; ATC antibody; ATD antibody; ATDC antibody; ATE antibody; ATM antibody; ATM serine/threonine kinase antibody; ATM_HUMAN antibody; DKFZp781A0353 antibody; MGC74674 antibody; OTTHUMP00000232981 antibody; Serine protein kinase ATM antibody; Serine-protein kinase ATM antibody; Serine/threonine-protein kinase ATM antibody; Tefu antibody; TEL1 antibody; TEL1; telomere maintenance 1; homolog antibody; TELO1 antibody; Telomere fusion protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13315
Immunogen : Peptide sequence around aa.1979~1983 (E-G-S-Q-S) derived from Human ATM.
Raised in : Rabbit
Species Reactivity : Human, Mouse
Tested Applications : ELISA, WB, IF; WB : 1 : 500-1 : 1000, IF : 1 : 100-1 : 200
Background : ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a reg µLator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1 checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are tho µght to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

Gupta A. et al. (2005) Mol Cell Biol. 25(12) : 5292-5305.
Bernstein JL. et al. (2002) Breast Cancer Res. 4(6) : 249-252.
Silverman J. et al. (2004) Genes Dev. 18(17) : 2108-2119.
Nakada D. et al. (2003) Nucleic Acids Res. 31(6) : 1715-1724.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conj µgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Conj µgate : Non-conj µgated
Buffer : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ATM
Research Areas : Epigenetics and Nuclear Signaling;Cancer