MAPKAPK5 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : MAP kinase-activated protein kinase 5 antibody; MAPK-activated protein kinase 5 antibody; MAPK5_HUMAN antibody; MAPKAP kinase 5 antibody; MAPKAPK-5 antibody; MAPKAPK5 antibody; Mitogen activated protein kinase activated protein kinase 5 antibody; p38-reg µLated/activated protein kinase antibody; PRAK antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8IW41
Immunogen : Recombinant Human MAP kinase-activated protein kinase 5 protein (200-471AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional reg µLation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1 p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional reg µLation of MYC by mediating phosphorylation of FOXO3 : phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional reg µLators of MYC that bind to the 3\'UTR of MYC transcript and prevent MYC translation. Acts as a negative reg µLator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4 : the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events : upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stim µLation, inducing F-actin rearrangement.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAPKAPK5
Research Areas : Cancer