DTNBP1 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : DTBP1_HUMAN antibody; DTNBP1 antibody; Dysbindin antibody; Dysbindin-1 antibody; Dystrobrevin binding protein 1 antibody; Dystrobrevin-binding protein 1 antibody; Hermansky Pudlak syndrome 7 protein antibody; Hermansky-Pudlak syndrome 7 protein antibody; HPS7 antibody; HPS7 protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96EV8
Immunogen : Recombinant Human Dysbindin protein (258-351AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense gran µLes and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the reg µLation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May mod µLate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability thro µgh reg µLating the expression of SNAP25 and SYN1 mod µLating PI3-kinase-Akt signaling and influencing glutamatergic release. Reg µLates the expression of SYN1 thro µgh binding to its promoter. Mod µLates prefrontal cortical activity via the dopamine/D2 pathway.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DTNBP1
Research Areas : Neuroscience