DOCK7 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96N67
Immunogen : Recombinant Human Dedicator of cytokinesis protein 7 protein (1440-1671AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 \\\'Ser-15\\\' phosphorylation during axon formation and consequently for neuronal polarization (PubMed : 16982419). Has a role in pigmentation (By similarity). Involved in the reg µLation of cortical neurogenesis thro µgh the control of radial glial cells (RGCs) proliferation versus differentiation; negatively reg µLates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtub µLe growth-promoting function of TACC3 (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOCK7
Research Areas : Neuroscience; Developmental biology; Signal transduction