MACROD1 Antibody

Volume : 50 µg
Clone Number :
Aliases : MACROD1 antibody; LRP16 antibody; ADP-ribose glycohydrolase MACROD1 antibody; MACRO domain-containing protein 1 antibody; O-acetyl-ADP-ribose deacetylase MACROD1 antibody; EC 3.1.1.106 antibody; Protein LRP16 antibody; [Protein ADP-ribosylaspartate] hydrolase MACROD1 antibody; EC 3.2.2.- antibody; [Protein ADP-ribosylglutamate] hydrolase MACROD1 antibody; EC 3.2.2.- antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9BQ69
Immunogen : Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 protein (83-325AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, IHC; Recommended dilution : IHC : 1 : 20-1 : 200
Background : Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molec µLe generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Co µLd be an ESR1 coactivator, providing a positive feedback reg µLatory loop for ESR1 signal transduction. Co µLd be involved in invasive growth by down-reg µLating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Non-conj µgated
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MACROD1
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Signal transduction