BARD1 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : BARD-1 antibody; Bard1 antibody; BARD1_HUMAN antibody; BRCA1 associated RING domain 1 antibody; BRCA1 associated RING domain gene 1 antibody; BRCA1 associated RING domain protein 1 antibody; BRCA1-associated RING domain protein 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q99728
Immunogen : Recombinant Human BRCA1-associated RING domain protein 1 protein (428-777AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of \'Lys-6\'-linked polyubiquitin chains and coordinates a diverse range of cell µLar pathways such as DNA damage repair, ubiquitination and transcriptional reg µLation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to mod µLate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3\' cleavage.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BARD1
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism