BRD7 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : 75 kDa bromodomain protein antibody; BP75 antibody; BRD 7 antibody; BRD7 antibody; BRD7_HUMAN antibody; Bromodomain containing 7 antibody; bromodomain containing protein 7 antibody; Bromodomain-containing protein 7 antibody; CELTIX 1 antibody; CELTIX1 antibody; NAG4 antibody; Protein CELTIX-1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NPI1
Immunogen : Recombinant Human Bromodomain-containing protein 7 protein (601-651AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively reg µLating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at \\\'Tyr-216\\\'. Down-reg µLates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-reg µLates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at \\\'Lys-9\\\' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at \\\'Lys-382\\\', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BRD7
Research Areas : Epigenetics and Nuclear Signaling; Cell biology