DCLRE1B Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : DCLRE1B antibody; SNM1B5' exonuclease Apollo antibody; EC 3.1.-.- antibody; DNA cross-link repair 1B protein antibody; SNM1 homolog B antibody; SNMIB antibody; hSNM1B antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H816
Immunogen : Recombinant Human 5\' exonuclease Apollo protein (345-493AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : 5\'-3\' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity : generates 3\' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are v µLnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1 TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage : plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCLRE1B
Research Areas : Others