DTL Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : Lethal(2) denticleless protein homolog antibody; CDW1 antibody; DCAF2 antibody; DDB1 and C µL4 associated factor 2 antibody; Ddb1- and C µL4-associated factor 2 antibody; Denticleless homolog antibody; Denticleless homolog (Drosophila) antibody; Denticleless protein homolog antibody; Dtl antibody; DTL_HUMAN antibody; L2DTL antibody; Lethal(2) denticleless protein homolog antibody; RA reg µLated nuclear matrix associated protein antibody; RAMP antibody; Retinoic acid reg µLated nuclear matrix associated protein antibody; Retinoic acid-reg µLated nuclear matrix-associated protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NZJ0
Immunogen : Recombinant Human Denticleless protein homolog protein (393-550AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Substrate-specific adapter of a DCX (DDB1-C µL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A (PubMed : 16861906, PubMed : 16949367, PubMed : 16964240, PubMed : 17085480, PubMed : 18703516, PubMed : 18794347, PubMed : 18794348, PubMed : 19332548, PubMed : 20129063, PubMed : 23478441 PubMed : 23478445, PubMed : 23677613). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle reg µLation of DNA replication (PubMed : 16861906, PubMed : 16949367, PubMed : 17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed : 18794348, PubMed : 19332548). KMT5A degradation is also important for a proper reg µLation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed : 23478445). Most substrates require their interaction with PCNA for their polyubiquitination : substrates interact with PCNA via their PIP-box, and those containing the \'K+4\' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the \'Lys-164\' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed : 20129063, PubMed : 23478441 PubMed : 23478445, PubMed : 23677613).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DTL
Research Areas : Cell biology