BOK Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Bcl 2 related ovarian killer protein antibody; Bcl-2-like protein 9 antibody; Bcl-2-related ovarian killer protein antibody; BCL2 related ovarian killer antibody; Bcl2-L-9 antibody; BCL2L9 antibody; BOK antibody; BOK_HUMAN antibody; BOKL antibody; Hbok antibody; MGC4631 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UMX3
Immunogen : Recombinant Human Bcl-2-related ovarian killer protein (15-103AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Isoform 1 : Apoptosis reg µLator that functions thro µgh different apoptotic signaling pathways (PubMed : 27076518, PubMed : 15102863, PubMed : 20673843). Plays a roles as pro-apoptotic protein that positively reg µLates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed : 27076518, PubMed : 15102863). In response to endoplasmic retic µLum stress promotes mitochondrial apoptosis thro µgh downstream BAX/BAK1 activation and positive reg µLation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 thro µgh induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, res µLting in cytochrome c release (PubMed : 27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed : 15102863). Plays a role in gran µLosa cell apoptosis by CASP3 activation (PubMed : 20673843). Plays a roles as anti-apoptotic protein during neuronal apototic process, by negatively reg µLating poly ADP-ribose polymerase-dependent cell death thro µgh reg µLation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may reg µLate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition thro µgh reg µLation of CCNE1 expression (PubMed : 19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed : 24113155).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BOK
Research Areas : Cell biology