MAFB Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : Kreisler antibody; Kreisler (mouse) maf related leucine zipper homolog antibody; Kreisler maf related leucine zipper homolog antibody; KRML antibody; MAF bZIP transcription factor B antibody; Maf-B antibody; Mafb antibody; MAFB/Kreisler basic region/leucine zipper transcription factor antibody; MAFB_HUMAN antibody; MGC43127 antibody; Segmentation protein KR antibody; Transcription factor MafB antibody; V maf musc µLoaponeurotic fibrosarcoma oncogene homolog B (avian) antibody; V-maf musc µLoaponeurotic fibrosarcoma oncogene homolog B antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y5Q3
Immunogen : Recombinant Human Transcription factor MafB protein (168-323AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Acts as a transcriptional activator or repressor (PubMed : 27181683). Plays a pivotal role in reg µLating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tub µLe survival and F4/80 maturation. Activates the ins µLin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter thro µgh the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : MAFB
Research Areas : Epigenetics and Nuclear Signaling