DACH2 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Transcription factor that is involved in reg µLation of organogenesis. Seems to be a reg µLator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in reg µLating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1 TBL1 HDAC1 and HDAC3. May be involved together with PAX3, SIX1 and EYA2 in reg µLation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is reg µLated by the overlying ectoderm, and DACH2 and PAX3 positively reg µLate each other's expression(By similarity). Probably binds to DNA via its DACHbox-N domain.
Immunogen : dachshund homolog 2(Drosophila)
Aliases :
Observed MW : 65 kDa
Uniprot ID : Q96NX9
Reactivity : Human, Mouse
Application : ELISA, WB
Recommended dilution : WB : 1 : 500-1 : 2000
Gene ID : 117154
Research Area : Metabolism, Developmental biology