DCUN1D1 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of c µLlin components of E3 c µLlin-RING ubiquitin ligase complexes. Acts by binding to c µLlin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8(UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the c µLlin substrates(PubMed : 25349211). Involved in the release of inhibitory effets of CAND1 on c µLlin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression(By similarity).
Immunogen : DCN1 defective in c µLlin neddylation 1 domain containing 1(S. cerevisiae)
Aliases : DCUN1L1 RP42, SCCRO
Observed MW : 28 kDa
Uniprot ID : Q96GG9
Reactivity : Human, Mouse, Rat
Application : ELISA, IHC, WB
Recommended dilution : WB : 1 : 500-1 : 2000; IHC : 1 : 20-1 : 200
Gene ID : 54165
Research Area : Metabolism