liver Arginase antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Arginase-1(Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical?marker?of hepatocell µLar differentiation in fine needle aspiration cytology and a marker?of hepatocytes and hepatocell µLar neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID : 12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID : 20071539).It can exsit as a homotrimer(PMID : 16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia(ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID : 27117406).
Immunogen : arginase, liver
Aliases : ARG1 Arginase 1 liver Arginase, Liver type arginase
Observed MW : 35 kDa
Uniprot ID : P05089
Reactivity : Human, Mouse, Rat
Application : ELISA, IHC, IP, IF, FC, WB
Recommended dilution : WB : 1 : 1000-1 : 10000; IP : 1 : 500-1 : 1000; IHC : 1 : 100-1 : 400; IF : 1 : 20-1 : 200
Gene ID : 383
Research Area : Signal Transduction, Metabolism